Nature Communications (Aug 2020)

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

  • Jing Zhang,
  • Marina A. Bellani,
  • Ryan C. James,
  • Durga Pokharel,
  • Yongqing Zhang,
  • John J. Reynolds,
  • Gavin S. McNee,
  • Andrew P. Jackson,
  • Grant S. Stewart,
  • Michael M. Seidman

DOI
https://doi.org/10.1038/s41467-020-17449-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.