PHARMACOLOGICAL INTERACTIONS OF STATINES WITH NON-INSULINAL ANTIDIABETIC AGENTS

Abstract

Introduction: dislipemia prevalence in type 2 diabetes is very often, between 35 to 56%; and despite new therapeutic options, statins continue being the drugs of first choice for treatment. Objectives: analyze the possible pharmacological interactions between statins and non-insulin drugs used in type 2 diabetic patients to normalize blood glucose. Inhibition of statins on HMG-CoA is highly selective, so pharmacodynamic interactions are not expected. But regarding pharmacokinetics, there are several levels where interactions with other drugs may occur. Three main levels of pharmacokinetic interactions have been described so far: membrane transporter OATP1B1, cytochrome P450 and absorption.

Keywords

• estatinas
• interacciones farmacológicas
• agentes diabéticos no insulínicos