BMC Pulmonary Medicine (Jul 2024)

Outcomes of biological therapy in patients with severe asthma with chronic rhinosinusitis in Saudi Arabia: patients with nasal polyps versus those without nasal polyps

  • Usama E. Abuelhassan,
  • Medhat Elnamaky,
  • Abdulaziz Alfifi,
  • Sultan K. Kadasah,
  • Mohammed A. Alshehri,
  • Haneen A. Alasiri,
  • Salihah Y. Al-Mani,
  • Ali S. Kadasah,
  • Abdullah Musleh,
  • Fawwaz A. Alshafa,
  • Muhammad S. S. Qureshi,
  • Abdulmohsen Y. Assiri,
  • Abdulrahman I. Falqi,
  • Bader I. Asiri,
  • Haider M. O. Ahmed,
  • Saleem Alshehri,
  • Fasih U. Rahman,
  • Muhammad Amir Qureshi,
  • Omar Abdelwahab,
  • Sherif Mohamed,
  • Ahmed R. I. Ali,
  • Saad M. A. Alqahtani,
  • Abdelrahman M. Abdalla

DOI
https://doi.org/10.1186/s12890-024-03139-x
Journal volume & issue
Vol. 24, no. 1
pp. 1 – 8

Abstract

Read online

Abstract Background This study’s purposes were to evaluate the impact of biological therapies on outcomes in patients with severe asthma (SA) and chronic rhinosinusitis (CRS) and to compare these effects among those with NP (CRSwNP) versus those without NP (CRSsNP) in the “real-world” setting in Saudi Arabian patients. Methods From March to September 2022, a retrospective observational cohort study was undertaken at the severe asthma clinics of the Armed Forces Hospital—Southern Region (AFHSR) and King Khalid University Hospital, Abha, Saudi Arabia, to delineate the effects of dupilumab therapy. Outcomes were assessed, including clinical outcomes, FEV1, and laboratory findings before and one year after dupilumab. Post-therapy effects were compared between CRSwNP and CRSsNP. Results Fifty subjects were enrolled, with a mean age of 46.56. There were 27 (54%) females and 23(46%) males. Significant improvements in clinical parameters (frequency of asthma exacerbations and hospitalizations, the use of OCs, anosmia, SNOTT-22, and the ACT), FEV1, and laboratory ones (serum IgE and eosinophilic count) were observed 6 and 12 months after using dupilumab (p < 0.001), respectively. However, after 12 months of dupilumab therapy, there were no significant differences between those with and without NP with regards to clinical (anosmia, ACT, and OCs use), laboratory (eosinophilic count, serum IgE level) parameters, and FEV1%. Conclusions Patients with CRS experienced significant improvements in clinical, FEV1, and laboratory outcomes after dupilumab therapy. However, these improvements were not maintained when comparing CRSwNP with CRSsNP. There were no significant differences between those with and without NP regarding ACT and OCs use or laboratory (eosinophilic count, serum IgE level) parameters. Further prospective multicenter studies are warranted.

Keywords