Nature Communications (Aug 2021)
The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients
- Matthieu Perreau,
- Madeleine Suffiotti,
- Pedro Marques-Vidal,
- Aurelie Wiedemann,
- Yves Levy,
- Cédric Laouénan,
- Jade Ghosn,
- Craig Fenwick,
- Denis Comte,
- Thierry Roger,
- Jean Regina,
- Peter Vollenweider,
- Gerard Waeber,
- Mauro Oddo,
- Thierry Calandra,
- Giuseppe Pantaleo
Affiliations
- Matthieu Perreau
- Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne
- Madeleine Suffiotti
- Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne
- Pedro Marques-Vidal
- Service of Internal Medicine, Department of Medicine, Lausanne University Hospital, University of Lausanne
- Aurelie Wiedemann
- Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955
- Yves Levy
- Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955
- Cédric Laouénan
- AP-HP, Hôpital Bichat, Département Épidémiologie Biostatistiques et Recherche Clinique, INSERM, Centre d’Investigation clinique-Epidémiologie Clinique 1425
- Jade Ghosn
- AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales
- Craig Fenwick
- Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne
- Denis Comte
- Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne
- Thierry Roger
- Service of Infectious Diseases, Lausanne University Hospital, University of Lausanne
- Jean Regina
- Service of Infectious Diseases, Lausanne University Hospital, University of Lausanne
- Peter Vollenweider
- Service of Internal Medicine, Department of Medicine, Lausanne University Hospital, University of Lausanne
- Gerard Waeber
- Service of Internal Medicine, Department of Medicine, Lausanne University Hospital, University of Lausanne
- Mauro Oddo
- Service of Intensive Care, Lausanne University Hospital, University of Lausanne
- Thierry Calandra
- Service of Infectious Diseases, Lausanne University Hospital, University of Lausanne
- Giuseppe Pantaleo
- Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-021-25191-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Infection with SARS CoV2 results in the induction of multiple cytokine and inflammatory pathways. Here the authors demonstrate the association of HGF and CXCL13 production with increased severity and mortality in COVID-19 patients.
