Nature Communications (Sep 2022)
Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4
- Qiang Luo,
- Jiezhen Mo,
- Hao Chen,
- Zetao Hu,
- Baihui Wang,
- Jiabing Wu,
- Ziyu Liang,
- Wenhao Xie,
- Kangxi Du,
- Maolin Peng,
- Yingping Li,
- Tianyang Li,
- Yangyi Zhang,
- Xiaoyan Shi,
- Wen-Hui Shen,
- Yang Shi,
- Aiwu Dong,
- Hailin Wang,
- Jinbiao Ma
Affiliations
- Qiang Luo
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Jiezhen Mo
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Hao Chen
- Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology
- Zetao Hu
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Baihui Wang
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Jiabing Wu
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Ziyu Liang
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Wenhao Xie
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Kangxi Du
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Maolin Peng
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Yingping Li
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Tianyang Li
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Yangyi Zhang
- Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology
- Xiaoyan Shi
- Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology
- Wen-Hui Shen
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Yang Shi
- Ludwig Institute for Cancer Research, Oxford University
- Aiwu Dong
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- Hailin Wang
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- Jinbiao Ma
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan University
- DOI
- https://doi.org/10.1038/s41467-022-33277-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.
