Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells

Qi Wang; Qiu Sun; Daniel M. Czajkowsky; Zhifeng Shao

doi:10.1038/s41467-017-02526-9

Nature Communications (Jan 2018)

Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells

Qi Wang,
Qiu Sun,
Daniel M. Czajkowsky,
Zhifeng Shao

Affiliations

Qi Wang: Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Qiu Sun: Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Daniel M. Czajkowsky: State Key Laboratory for Oncogenes and Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University
Zhifeng Shao: State Key Laboratory for Oncogenes and Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-017-02526-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Topologically associating domain (TAD) boundaries in flies seem to be different from those in mammals. Here, the authors use Hi-C with sub-kb resolution to identify about 4000 TADs in flies, most demarcated by the insulator complexes BEAF-32/CP190 or BEAF-32/Chromator like CTCF/cohesin in mammals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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