Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation

Brener C. Carvalho; Leonardo C. Oliveira; Carolina D. Rocha; Heliana B. Fernandes; Isadora M. Oliveira; Felipe B. Leãõ; Thalita M. Valverde; Igor M.G. Rego; Sankar Ghosh; Aristóbolo M. Silva

Data in Brief (Jun 2019)

Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation

Brener C. Carvalho,
Leonardo C. Oliveira,
Carolina D. Rocha,
Heliana B. Fernandes,
Isadora M. Oliveira,
Felipe B. Leãõ,
Thalita M. Valverde,
Igor M.G. Rego,
Sankar Ghosh,
Aristóbolo M. Silva

Affiliations

Brener C. Carvalho: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Leonardo C. Oliveira: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University, New York, NY, USA
Carolina D. Rocha: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Heliana B. Fernandes: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Isadora M. Oliveira: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Felipe B. Leãõ: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Thalita M. Valverde: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Igor M.G. Rego: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Sankar Ghosh: Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University, New York, NY, USA
Aristóbolo M. Silva: Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Corresponding author.

Journal volume & issue: Vol. 24

Abstract

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We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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