Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman

Abstract

General and stereoselective synthesis of tetracyclic isochroman-containing polyketide oligomers is challenging. Here, the authors report on an Au(I)/chiral Sc(III) bimetallic catalyst for a biomimetic asymmetric hetero-Diels–Alder reaction for in-situ generation of isochromene and ortho-quinonemethide.