Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

Ken-ichiro Nakajima; Zhenzhong Cui; Chia Li; Jaroslawna Meister; Yinghong Cui; Ou Fu; Adam S. Smith; Shalini Jain; Bradford B. Lowell; Michael J. Krashes; Jürgen Wess

doi:10.1038/ncomms10268

Nature Communications (Jan 2016)

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

Ken-ichiro Nakajima,
Zhenzhong Cui,
Chia Li,
Jaroslawna Meister,
Yinghong Cui,
Ou Fu,
Adam S. Smith,
Shalini Jain,
Bradford B. Lowell,
Michael J. Krashes,
Jürgen Wess

Affiliations

Ken-ichiro Nakajima: Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Zhenzhong Cui: Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Chia Li: Diabetes Endocrine and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases
Jaroslawna Meister: Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Yinghong Cui: Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Ou Fu: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Adam S. Smith: Section on Neural Gene Expression, National Institute of Mental Health
Shalini Jain: Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Bradford B. Lowell: Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
Michael J. Krashes: Diabetes Endocrine and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases
Jürgen Wess: Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases

DOI: https://doi.org/10.1038/ncomms10268
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Hypothalamic Agouti-related peptide (AgRP) neurons play a key role in regulating food intake. Here, the authors report a novel pathway in which activation of Gs-coupled receptors on AgRP neurons leads to robust, sustained increase in food intake.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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