Risk Factors for Development and Severity of COVID-19 in COPD Patients

Matteo Bonato; Matteo Bonato; Umberto Semenzato; Mariaenrica Tinè; Erica Bazzan; Marco Damin; Davide Biondini; Alvise Casara; Micaela Romagnoli; Graziella Turato; Manuel G. Cosio; Manuel G. Cosio; Marina Saetta; Simonetta Baraldo

doi:10.3389/fmed.2021.714570

Frontiers in Medicine (Aug 2021)

Risk Factors for Development and Severity of COVID-19 in COPD Patients

Matteo Bonato,
Matteo Bonato,
Umberto Semenzato,
Mariaenrica Tinè,
Erica Bazzan,
Marco Damin,
Davide Biondini,
Alvise Casara,
Micaela Romagnoli,
Graziella Turato,
Manuel G. Cosio,
Manuel G. Cosio,
Marina Saetta,
Simonetta Baraldo

Affiliations

Matteo Bonato: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Matteo Bonato: Pulmonology Unit, Ospedale Ca' Foncello, Azienda Unità Locale Socio Sanitaria 2 (AULSS2) Marca Trevigiana, Treviso, Italy
Umberto Semenzato: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Mariaenrica Tinè: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Erica Bazzan: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Marco Damin: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Davide Biondini: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Alvise Casara: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Micaela Romagnoli: Pulmonology Unit, Ospedale Ca' Foncello, Azienda Unità Locale Socio Sanitaria 2 (AULSS2) Marca Trevigiana, Treviso, Italy
Graziella Turato: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Manuel G. Cosio: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Manuel G. Cosio: Respiratory Division, Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada
Marina Saetta: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy
Simonetta Baraldo: Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, Padova, Italy

DOI: https://doi.org/10.3389/fmed.2021.714570
Journal volume & issue: Vol. 8

Abstract

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The impact that COVID-19 could have on patients with COPD is a real concern. In this study we evaluated, in a cohort of longitudinally followed COPD subjects, the incidence of COVID-19, seeking for possible risk factors and prognostic factors predicting the clinical outcome. In our cohort of 370 patients (followed for 5.3 ± 2.7 years), 22 developed COVID-19 (COPD/COVID-19+) between February/November 2020 (5.9%). Cardio-metabolic conditions (hypertension, dyslipidemia, obesity, diabetes) but not respiratory abnormalities (FEV1, DLCO, emphysema and exacerbation history), were risk factors for development of COVID-19 in COPD patients. Out of the 22 COPD/COVID-19+ patients, 10 needed intensive care. Low DLCO and emphysema, but also metabolic comorbidities, were related to the need for intensive care.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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