Nature Communications (May 2021)
Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival
- Stefania Dispinseri,
- Massimiliano Secchi,
- Maria Franca Pirillo,
- Monica Tolazzi,
- Martina Borghi,
- Cristina Brigatti,
- Maria Laura De Angelis,
- Marco Baratella,
- Elena Bazzigaluppi,
- Giulietta Venturi,
- Francesca Sironi,
- Andrea Canitano,
- Ilaria Marzinotto,
- Cristina Tresoldi,
- Fabio Ciceri,
- Lorenzo Piemonti,
- Donatella Negri,
- Andrea Cara,
- Vito Lampasona,
- Gabriella Scarlatti
Affiliations
- Stefania Dispinseri
- Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele
- Massimiliano Secchi
- Diabetes Research Institute, IRCCS Ospedale San Raffaele
- Maria Franca Pirillo
- National Center for Global Health, Istituto Superiore di Sanità
- Monica Tolazzi
- Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele
- Martina Borghi
- Department of Infectious Diseases, Istituto Superiore di Sanità
- Cristina Brigatti
- Diabetes Research Institute, IRCCS Ospedale San Raffaele
- Maria Laura De Angelis
- Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità
- Marco Baratella
- Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele
- Elena Bazzigaluppi
- Diabetes Research Institute, IRCCS Ospedale San Raffaele
- Giulietta Venturi
- Department of Infectious Diseases, Istituto Superiore di Sanità
- Francesca Sironi
- Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele
- Andrea Canitano
- National Center for Global Health, Istituto Superiore di Sanità
- Ilaria Marzinotto
- Diabetes Research Institute, IRCCS Ospedale San Raffaele
- Cristina Tresoldi
- Molecular Hematology Unit, IRCCS Ospedale San Raffaele
- Fabio Ciceri
- Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele
- Lorenzo Piemonti
- Diabetes Research Institute, IRCCS Ospedale San Raffaele
- Donatella Negri
- Department of Infectious Diseases, Istituto Superiore di Sanità
- Andrea Cara
- National Center for Global Health, Istituto Superiore di Sanità
- Vito Lampasona
- Diabetes Research Institute, IRCCS Ospedale San Raffaele
- Gabriella Scarlatti
- Viral Evolution and Transmission Unit, IRCCS Ospedale San Raffaele
- DOI
- https://doi.org/10.1038/s41467-021-22958-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Antibody responses are critical for protection from developing severe COVID-19 following SARS-CoV-2 infection. Here the authors show that antibody responses against SARS-CoV-2 spike protein correlate with neutralizing capacity and protection, are not affected by heterologous boosting of influenza or common cold immunity, and can last up to 8 months.
