Nature Communications (Aug 2020)
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
- Thomas D. Madsen,
- Lasse H. Hansen,
- John Hintze,
- Zilu Ye,
- Shifa Jebari,
- Daniel B. Andersen,
- Hiren J. Joshi,
- Tongzhong Ju,
- Jens P. Goetze,
- Cesar Martin,
- Mette M. Rosenkilde,
- Jens J. Holst,
- Rune E. Kuhre,
- Christoffer K. Goth,
- Sergey Y. Vakhrushev,
- Katrine T. Schjoldager
Affiliations
- Thomas D. Madsen
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Lasse H. Hansen
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- John Hintze
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Zilu Ye
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Shifa Jebari
- Biofisika Institute (UPV/EHU, CSIC), Departamento de Bioquímica, Universidad del País Vasco
- Daniel B. Andersen
- Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen
- Hiren J. Joshi
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Tongzhong Ju
- Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration
- Jens P. Goetze
- Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen
- Cesar Martin
- Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration
- Mette M. Rosenkilde
- Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen
- Jens J. Holst
- Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen
- Rune E. Kuhre
- Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen
- Christoffer K. Goth
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Sergey Y. Vakhrushev
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Katrine T. Schjoldager
- Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-020-17473-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate peptide half-lives and receptor activation properties.
