Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma

Nichole R. Dean; Larissa Sweeny; J. Scott Magnuson; William R. Carroll; Daniel Robinson; Renee A. Desmond; Eben L. Rosenthal

doi:10.1155/2011/972497

Journal of Skin Cancer (Jan 2011)

Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma

Nichole R. Dean,
Larissa Sweeny,
J. Scott Magnuson,
William R. Carroll,
Daniel Robinson,
Renee A. Desmond,
Eben L. Rosenthal

Affiliations

Nichole R. Dean: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA
Larissa Sweeny: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA
J. Scott Magnuson: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA
William R. Carroll: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA
Daniel Robinson: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA
Renee A. Desmond: Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 25294, USA
Eben L. Rosenthal: Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USA

DOI: https://doi.org/10.1155/2011/972497
Journal volume & issue: Vol. 2011

Abstract

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Recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of the head and neck was performed (n=72). Data regarding tumor site, stage, treatment, parotid involvement, perineural invasion, positive margins, metastasis, and disease-free survival was analyzed. The majority of patients were male (85%) and presented with recurrent stage III (89%) cSCC. Two-year disease-free survival was 62% and decreased to 47% at 5 years. Parotid involvement, positive margins, nodal metastasis, or the presence of perineural invasion did not correlate with decreased survival (P>.05). Distant metastasis was a strong indicator of poor overall survival (P<.001). Adjuvant postoperative radiotherapy did not improve overall survival (P=.42). Overall survival was poor for patients with advanced recurrent cSCC despite the combined treatment with surgery and radiotherapy.

Published in Journal of Skin Cancer

ISSN: 2090-2905 (Print); 2090-2913 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://onlinelibrary.wiley.com/journal/9158

About the journal