Membrane-mediated protein interactions drive membrane protein organization

Yining Jiang; Batiste Thienpont; Vinay Sapuru; Richard K. Hite; Jeremy S. Dittman; James N. Sturgis; Simon Scheuring

doi:10.1038/s41467-022-35202-8

Nature Communications (Nov 2022)

Membrane-mediated protein interactions drive membrane protein organization

Yining Jiang,
Batiste Thienpont,
Vinay Sapuru,
Richard K. Hite,
Jeremy S. Dittman,
James N. Sturgis,
Simon Scheuring

Affiliations

Yining Jiang: Biochemistry & Structural Biology, Cell & Developmental Biology, and Molecular Biology (BCMB) Program, Weill Cornell Graduate School of Biomedical Sciences
Batiste Thienpont: Laboratoire d’Ingénierie des Systèmes Macromoléculaires (LISM), Unité Mixte de Recherche (UMR) 7255, Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université
Vinay Sapuru: Structural Biology Program, Memorial Sloan Kettering Cancer Center
Richard K. Hite: Structural Biology Program, Memorial Sloan Kettering Cancer Center
Jeremy S. Dittman: Weill Cornell Medicine, Department of Biochemistry
James N. Sturgis: Laboratoire d’Ingénierie des Systèmes Macromoléculaires (LISM), Unité Mixte de Recherche (UMR) 7255, Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université
Simon Scheuring: Weill Cornell Medicine, Department of Anesthesiology

DOI: https://doi.org/10.1038/s41467-022-35202-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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High-Speed Atomic Force Microscopy movies of membrane proteins — diffusing and interacting in bilayers of controlled thickness — allow the determination of membrane-mediated membrane protein interaction energetics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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