Nature Communications (Nov 2018)
High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
- Gloria V. Echeverria,
- Emily Powell,
- Sahil Seth,
- Zhongqi Ge,
- Alessandro Carugo,
- Christopher Bristow,
- Michael Peoples,
- Frederick Robinson,
- Huan Qiu,
- Jiansu Shao,
- Sabrina L. Jeter-Jones,
- Xiaomei Zhang,
- Vandhana Ramamoorthy,
- Shirong Cai,
- Wenhui Wu,
- Giulio Draetta,
- Stacy L. Moulder,
- William F. Symmans,
- Jeffrey T. Chang,
- Timothy P. Heffernan,
- Helen Piwnica-Worms
Affiliations
- Gloria V. Echeverria
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Emily Powell
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Sahil Seth
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Zhongqi Ge
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Alessandro Carugo
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Christopher Bristow
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Michael Peoples
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Frederick Robinson
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Huan Qiu
- Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center
- Jiansu Shao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Sabrina L. Jeter-Jones
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xiaomei Zhang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Vandhana Ramamoorthy
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Shirong Cai
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Wenhui Wu
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Giulio Draetta
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Stacy L. Moulder
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- William F. Symmans
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Jeffrey T. Chang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Timothy P. Heffernan
- Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
- Helen Piwnica-Worms
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-07406-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
It is unclear how intra-tumoral heterogeneity contributes to metastasis. Here the authors study the clonal dynamics of triple negative breast cancer metastasis using patient derived xenografts and demonstrate that primary tumor clones harbor properties that support seeding and colonization of multiple organs.
