Does gene length play a role? — Transient regulation of Gcn5 histone acetyltransferase under stress conditions

Abstract

Gcn5 is a histone modification enzyme that performs its function by global or locus-specific histone acetylation. It is known that Gcn5 involves in stress responses in yeast. Our previous data showed that Gcn5 relocalized to the long genes under IM KCl stress conditions in yeast. Here we use a stress adaptation and recovery model and performed 52 microarrays. By investigating the gene regulation pattern, genome-wide localization of Gcn5, as well as histone modification, we aim to understand the regulation mechanism. The data is available in Gene Expression Omnibus (GEO: SuperSeriesGSE 36601).

Keywords

• Gcn5
• Microarray
• Genome-wide
• Gene length
• Epigenetic regulation