Nature Communications (Feb 2019)
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
- Maik Luu,
- Sabine Pautz,
- Vanessa Kohl,
- Rajeev Singh,
- Rossana Romero,
- Sébastien Lucas,
- Jörg Hofmann,
- Hartmann Raifer,
- Niyati Vachharajani,
- Lucia Campos Carrascosa,
- Boris Lamp,
- Andrea Nist,
- Thorsten Stiewe,
- Yoav Shaul,
- Till Adhikary,
- Mario M. Zaiss,
- Matthias Lauth,
- Ulrich Steinhoff,
- Alexander Visekruna
Affiliations
- Maik Luu
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Sabine Pautz
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Vanessa Kohl
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Rajeev Singh
- Institute of Molecular Biology and Tumor Research, Center for Tumor- and Immunobiology, Philipps-University Marburg
- Rossana Romero
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Sébastien Lucas
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University-Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Jörg Hofmann
- Division of Biochemistry, Department of Biology, Friedrich-Alexander-University-Erlangen-Nürnberg
- Hartmann Raifer
- Flow Cytometry Core Facility, Philipps-University Marburg
- Niyati Vachharajani
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Lucia Campos Carrascosa
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Boris Lamp
- Genomics Core Facility, Philipps-University Marburg
- Andrea Nist
- Genomics Core Facility, Philipps-University Marburg
- Thorsten Stiewe
- Genomics Core Facility, Philipps-University Marburg
- Yoav Shaul
- Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Till Adhikary
- Institute of Molecular Biology and Tumor Research, Center for Tumor- and Immunobiology, Philipps-University Marburg
- Mario M. Zaiss
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University-Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Matthias Lauth
- Institute of Molecular Biology and Tumor Research, Center for Tumor- and Immunobiology, Philipps-University Marburg
- Ulrich Steinhoff
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- Alexander Visekruna
- Institute for Medical Microbiology and Hygiene, Philipps-University Marburg
- DOI
- https://doi.org/10.1038/s41467-019-08711-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.
