Nature Communications (Jan 2022)
MicroRNA-365 regulates human cardiac action potential duration
- Dena Esfandyari,
- Bio Maria Ghéo Idrissou,
- Konstantin Hennis,
- Petros Avramopoulos,
- Anne Dueck,
- Ibrahim El-Battrawy,
- Laurenz Grüter,
- Melanie Annemarie Meier,
- Anna Christina Näger,
- Deepak Ramanujam,
- Tatjana Dorn,
- Thomas Meitinger,
- Christian Hagl,
- Hendrik Milting,
- Martin Borggrefe,
- Stefanie Fenske,
- Martin Biel,
- Andreas Dendorfer,
- Yassine Sassi,
- Alessandra Moretti,
- Stefan Engelhardt
Affiliations
- Dena Esfandyari
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Bio Maria Ghéo Idrissou
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Konstantin Hennis
- Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München
- Petros Avramopoulos
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Anne Dueck
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Ibrahim El-Battrawy
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
- Laurenz Grüter
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Melanie Annemarie Meier
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Anna Christina Näger
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Deepak Ramanujam
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Tatjana Dorn
- Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich (TUM)
- Thomas Meitinger
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
- Christian Hagl
- Clinic of Cardiac Surgery, University Hospital, Ludwig-Maximilians-Universität München
- Hendrik Milting
- Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum
- Martin Borggrefe
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
- Stefanie Fenske
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
- Martin Biel
- Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München
- Andreas Dendorfer
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
- Yassine Sassi
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- Alessandra Moretti
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
- Stefan Engelhardt
- Institute of Pharmacology and Toxicology, Technical University of Munich (TUM)
- DOI
- https://doi.org/10.1038/s41467-021-27856-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.
