Facile CuCl2·2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides

Rafaila Rafique; Syed Muhammad Saad; Arshia; Khalid Mohammed Khan; Shahnaz Perveen; Muhammad Taha

Journal of Saudi Chemical Society (Jan 2020)

Facile CuCl2·2H2O catalyzed one-pot conversion of dimedone into highly functionalized indazole based N-arylhydrazinecarbothioamides

Rafaila Rafique,
Syed Muhammad Saad,
Arshia,
Khalid Mohammed Khan,
Shahnaz Perveen,
Muhammad Taha

Affiliations

Rafaila Rafique: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Syed Muhammad Saad: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Chemistry, University of Karachi, Karachi 75270, Pakistan
Arshia: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Khalid Mohammed Khan: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia; Corresponding author at: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Shahnaz Perveen: PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi 75280, Pakistan
Muhammad Taha: Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia

Journal volume & issue: Vol. 24, no. 1
pp. 92 – 97

Abstract

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A convenient and facile CuCl2·2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be moderate to good without purification requirements. Structural features of the synthetic compounds were confirmed by various spectroscopic techniques such as 1H NMR, 13C NMR, EI-MS, FAB-MS, HREI-MS, and HRFAB-MS. The reaction intermediates were also quenched and characterized. Plausible reaction mechanisms were also discussed. Keywords: One-pot synthesis, Dimedone, Indazole, Carbothioamides

Published in Journal of Saudi Chemical Society

ISSN: 1319-6103 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/journal-of-saudi-chemical-society/

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