Nature Communications (Mar 2019)
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
- Fiona Allum,
- Åsa K. Hedman,
- Xiaojian Shao,
- Warren A. Cheung,
- Jinchu Vijay,
- Frédéric Guénard,
- Tony Kwan,
- Marie-Michelle Simon,
- Bing Ge,
- Cristiano Moura,
- Elodie Boulier,
- Lars Rönnblom,
- Sasha Bernatsky,
- Mark Lathrop,
- Mark I. McCarthy,
- Panos Deloukas,
- André Tchernof,
- Tomi Pastinen,
- Marie-Claude Vohl,
- Elin Grundberg
Affiliations
- Fiona Allum
- Department of Human Genetics, McGill University
- Åsa K. Hedman
- Department of Medicine Solna, Cardiovascular Medicine Unit, Karolinska Institute
- Xiaojian Shao
- Department of Human Genetics, McGill University
- Warren A. Cheung
- Department of Human Genetics, McGill University
- Jinchu Vijay
- Department of Human Genetics, McGill University
- Frédéric Guénard
- Institute of Nutrition and Functional Foods (INAF), Université Laval
- Tony Kwan
- Department of Human Genetics, McGill University
- Marie-Michelle Simon
- Department of Human Genetics, McGill University
- Bing Ge
- Department of Human Genetics, McGill University
- Cristiano Moura
- Department of Epidemiology, McGill University
- Elodie Boulier
- Department of Human Genetics, McGill University
- Lars Rönnblom
- Department of Medical Sciences, Uppsala University
- Sasha Bernatsky
- Department of Epidemiology, McGill University
- Mark Lathrop
- Department of Human Genetics, McGill University
- Mark I. McCarthy
- Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford
- Panos Deloukas
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- André Tchernof
- Québec Heart and Lung Institute, Université Laval
- Tomi Pastinen
- Department of Human Genetics, McGill University
- Marie-Claude Vohl
- Institute of Nutrition and Functional Foods (INAF), Université Laval
- Elin Grundberg
- Department of Human Genetics, McGill University
- DOI
- https://doi.org/10.1038/s41467-019-09184-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Obesity and related metabolic complications represent an important health burden. Here the authors carry out a methylC-capture sequencing-based epigenome-wide association study to link circulating plasma lipid levels, CpG methylation and cardiometabolic risk across adipose and blood tissues.
