Neural mechanisms of contextual modulation in the retinal direction selective circuit

Abstract

The mechanisms of contextual modulation in direction selective ganglion cells in the retina remain unclear. Here, the authors find that that On-Off direction-selective ganglion cells are differentially sensitive to discontinuities of dark and bright moving edges in the visual environment and, using synapse-specific genetic manipulations with functional measurements, reveal the microcircuits underlying this contextual sensitivity.