Artificial Cells, Nanomedicine, and Biotechnology (Dec 2024)

Advances in nanotechnology-assisted photodynamic therapy for neurological disorders: a comprehensive review

  • Abdul Nasir,
  • Mujeeb Ur Rehman,
  • Tamreez Khan,
  • Mansoor Husn,
  • Manzar Khan,
  • Ahmad Khan,
  • Abdifatah Mohamed Nuh,
  • Wei Jiang,
  • Hafiz Muhammad Umer Farooqi,
  • Qain Bai

DOI
https://doi.org/10.1080/21691401.2024.2304814
Journal volume & issue
Vol. 52, no. 1
pp. 84 – 103

Abstract

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AbstractNeurological disorders such as neurodegenerative diseases and nervous system tumours affect more than one billion people throughout the globe. The physiological sensitivity of the nervous tissue limits the application of invasive therapies and leads to poor treatment and prognosis. One promising solution that has generated attention is Photodynamic therapy (PDT), which can potentially revolutionise the treatment landscape for neurological disorders. PDT attracted substantial recognition for anticancer efficacy and drug conjugation for targeted drug delivery. This review thoroughly explained the basic principles of PDT, scientific interventions and advances in PDT, and their complicated mechanism in treating brain-related pathologies. Furthermore, the merits and demerits of PDT in the context of neurological disorders offer a well-rounded perspective on its feasibility and challenges. In conclusion, this review encapsulates the significant potential of PDT in transforming the treatment landscape for neurological disorders, emphasising its role as a non-invasive, targeted therapeutic approach with multifaceted applications.

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