Frontiers in Cell and Developmental Biology (Jan 2022)
Comparison of Tendon Development Versus Tendon Healing and Regeneration
- Peiwen He,
- Peiwen He,
- Peiwen He,
- Peiwen He,
- Dengfeng Ruan,
- Dengfeng Ruan,
- Dengfeng Ruan,
- Zizhan Huang,
- Zizhan Huang,
- Zizhan Huang,
- Canlong Wang,
- Canlong Wang,
- Canlong Wang,
- Yiwen Xu,
- Yiwen Xu,
- Yiwen Xu,
- Honglu Cai,
- Honglu Cai,
- Honglu Cai,
- Hengzhi Liu,
- Hengzhi Liu,
- Hengzhi Liu,
- Yang Fei,
- Yang Fei,
- Yang Fei,
- Boon Chin Heng,
- Weishan Chen,
- Weishan Chen,
- Weishan Chen,
- Weiliang Shen,
- Weiliang Shen,
- Weiliang Shen,
- Weiliang Shen,
- Weiliang Shen,
- Weiliang Shen
Affiliations
- Peiwen He
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Peiwen He
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Peiwen He
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Peiwen He
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, China
- Dengfeng Ruan
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Dengfeng Ruan
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Dengfeng Ruan
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Zizhan Huang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Zizhan Huang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Zizhan Huang
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Canlong Wang
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Canlong Wang
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Canlong Wang
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Yiwen Xu
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Yiwen Xu
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Yiwen Xu
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Honglu Cai
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Honglu Cai
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Honglu Cai
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Hengzhi Liu
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Hengzhi Liu
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Hengzhi Liu
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Yang Fei
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Yang Fei
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Yang Fei
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Boon Chin Heng
- Central Laboratory, Peking University School of Stomatology, Bejing, China
- Weishan Chen
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Weishan Chen
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Weishan Chen
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Weiliang Shen
- Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Weiliang Shen
- Orthopedics Research Institute of Zhejiang University, Hangzhou, China
- Weiliang Shen
- Institute of Sports Medicine, Zhejiang University, Hangzhou, China
- Weiliang Shen
- Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, China
- Weiliang Shen
- Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, China
- Weiliang Shen
- China Orthopaedic Regenerative Medicine (CORMed), Hangzhou, China
- DOI
- https://doi.org/10.3389/fcell.2022.821667
- Journal volume & issue
-
Vol. 10
Abstract
Tendon is a vital connective tissue in human skeletal muscle system, and tendon injury is very common and intractable in clinic. Tendon development and repair are two closely related but still not fully understood processes. Tendon development involves multiple germ layer, as well as the regulation of diversity transcription factors (Scx et al.), proteins (Tnmd et al.) and signaling pathways (TGFβ et al.). The nature process of tendon repair is roughly divided in three stages, which are dominated by various cells and cell factors. This review will describe the whole process of tendon development and compare it with the process of tendon repair, focusing on the understanding and recent advances in the regulation of tendon development and repair. The study and comparison of tendon development and repair process can thus provide references and guidelines for treatment of tendon injuries.
Keywords
