Nature Communications (Jul 2016)
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
- Katannya Kapeli,
- Gabriel A. Pratt,
- Anthony Q. Vu,
- Kasey R. Hutt,
- Fernando J. Martinez,
- Balaji Sundararaman,
- Ranjan Batra,
- Peter Freese,
- Nicole J. Lambert,
- Stephanie C. Huelga,
- Seung J. Chun,
- Tiffany Y. Liang,
- Jeremy Chang,
- John P. Donohue,
- Lily Shiue,
- Jiayu Zhang,
- Haining Zhu,
- Franca Cambi,
- Edward Kasarskis,
- Shawn Hoon,
- Manuel Ares Jr.,
- Christopher B. Burge,
- John Ravits,
- Frank Rigo,
- Gene W. Yeo
Affiliations
- Katannya Kapeli
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Gabriel A. Pratt
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Anthony Q. Vu
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Kasey R. Hutt
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Fernando J. Martinez
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Balaji Sundararaman
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Ranjan Batra
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Peter Freese
- Department of Biology, MIT
- Nicole J. Lambert
- Department of Biology, MIT
- Stephanie C. Huelga
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Seung J. Chun
- Ionis Pharmaceuticals
- Tiffany Y. Liang
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Jeremy Chang
- Department of Cellular and Molecular Medicine, University of California at San Diego
- John P. Donohue
- Department of Molecular, Cell and Developmental Biology, Sinsheimer Labs, University of California
- Lily Shiue
- Department of Molecular, Cell and Developmental Biology, Sinsheimer Labs, University of California
- Jiayu Zhang
- Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky
- Haining Zhu
- Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky
- Franca Cambi
- Department of Neurology, University of Kentucky
- Edward Kasarskis
- Department of Neurology, University of Kentucky
- Shawn Hoon
- Molecular Engineering Laboratory, A*STAR
- Manuel Ares Jr.
- Department of Molecular, Cell and Developmental Biology, Sinsheimer Labs, University of California
- Christopher B. Burge
- Department of Biology, MIT
- John Ravits
- Department of Neurosciences, University of California at San Diego
- Frank Rigo
- Ionis Pharmaceuticals
- Gene W. Yeo
- Department of Cellular and Molecular Medicine, University of California at San Diego
- DOI
- https://doi.org/10.1038/ncomms12143
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Abnormal functions of RNA-binding proteins TAF15, FUS and TDP43 are associated with amyotrophic lateral sclerosis. Here, Kapeli et al. characterize the RNA targets of TAF15 and identify points of convergence and divergence between the targets of TAF15, FUS and TDP43 in several neuronal systems.
