Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

Yiming Zhao; François Fay; Sjoerd Hak; Jose Manuel Perez-Aguilar; Brenda L. Sanchez-Gaytan; Brandon Goode; Raphaël Duivenvoorden; Catharina de Lange Davies; Astrid Bjørkøy; Harel Weinstein; Zahi A. Fayad; Carlos Pérez-Medina; Willem J. M. Mulder

doi:10.1038/ncomms11221

Nature Communications (Apr 2016)

Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

Yiming Zhao,
François Fay,
Sjoerd Hak,
Jose Manuel Perez-Aguilar,
Brenda L. Sanchez-Gaytan,
Brandon Goode,
Raphaël Duivenvoorden,
Catharina de Lange Davies,
Astrid Bjørkøy,
Harel Weinstein,
Zahi A. Fayad,
Carlos Pérez-Medina,
Willem J. M. Mulder

Affiliations

Yiming Zhao: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
François Fay: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
Sjoerd Hak: Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology
Jose Manuel Perez-Aguilar: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University
Brenda L. Sanchez-Gaytan: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
Brandon Goode: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
Raphaël Duivenvoorden: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
Catharina de Lange Davies: Department of Physics, The Norwegian University of Science and Technology
Astrid Bjørkøy: Department of Physics, The Norwegian University of Science and Technology
Harel Weinstein: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University
Zahi A. Fayad: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
Carlos Pérez-Medina: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai
Willem J. M. Mulder: Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/ncomms11221
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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The in vivoanticancer efficacy of nanoparticle-mediated drug delivery depends on the association between the drug and its carrier. Here, the authors use FRET to show that the drug hydrophobicity, and miscibility with the carrier, influence nanoparticle accumulation in murine tumour models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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