The efficiency of antiviral therapy in patients with chronic hepatitis C infected with hepatitis C virus recombinants

Abstract

The review gives the data available in the literature on the efficiency of treatment in patients with chronic hepatitis C infected with hepatitis C virus (HCV) recombinants, by applying various antiviral therapy regimens. The low efficiency of treatment with pegylated interferons (PEG IFN) + ribavirin (RIB) and sofosburin (SOF) + RIB in this patient group (a sustained virologic response was achieved in 22 and 30.7%, respectively) compared with the efficiency of treatment (87—97 and 83—97%, respectively) in patients infected with HCV genotype 2 does not allow the 2015 EASL HCV genotype 2 treatment regimens to be used in such patients. In this connection, subtyping genotype 2 isolates by NS5B sequencing should be introduced into clinical laboratory practice to successfully detect recombinant HCVs and to enhance the efficiency of antiviral therapy.

Keywords

• hepatitis c virus recombinants
• rf2k/1b
• chronic hepatitis c
• antiviral therapy
• ns5b sequencing
• rf2k/1b