Frontiers in Aging Neuroscience (Aug 2021)
The Mechanisms of Sevoflurane-Induced Neuroinflammation
- Xiangfei Huang,
- Xiangfei Huang,
- Jun Ying,
- Jun Ying,
- Danying Yang,
- Danying Yang,
- Pu Fang,
- Xifeng Wang,
- Bin Zhou,
- Bin Zhou,
- Lieliang Zhang,
- Lieliang Zhang,
- Yang Fang,
- Yang Fang,
- Wen Yu,
- Wen Yu,
- Xing Liu,
- Xing Liu,
- Qingcui Zhen,
- Qingcui Zhen,
- Fuzhou Hua,
- Fuzhou Hua
Affiliations
- Xiangfei Huang
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Xiangfei Huang
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Jun Ying
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Jun Ying
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Danying Yang
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Danying Yang
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Pu Fang
- Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China
- Xifeng Wang
- Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
- Bin Zhou
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Bin Zhou
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Lieliang Zhang
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Lieliang Zhang
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Yang Fang
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Yang Fang
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Wen Yu
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Wen Yu
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Xing Liu
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Xing Liu
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Qingcui Zhen
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Qingcui Zhen
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- Fuzhou Hua
- Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China
- Fuzhou Hua
- Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China
- DOI
- https://doi.org/10.3389/fnagi.2021.717745
- Journal volume & issue
-
Vol. 13
Abstract
Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation was most widely mentioned among the established mechanisms of sevoflurane-induced cognitive dysfunction, its upstream mechanisms have yet to be illustrated. Thus, we reviewed the relevant literature and discussed the most mentioned mechanisms, including the modulation of the microglial function, blood–brain barrier (BBB) breakdown, changes in gut microbiota, and ease of cholinergic neurotransmission to help us understand the properties of sevoflurane, providing us new perspectives for the prevention of sevoflurane-induced cognitive impairment.
Keywords
- sevoflurane
- neuroinflammation
- microglia
- blood–brain barrier
- gut microbiota
- cholinergic neurotransmission
