Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Simona Valletta; Alexander Thomas; Yiran Meng; Xiying Ren; Roy Drissen; Hilal Sengül; Cristina Di Genua; Claus Nerlov

doi:10.1038/s41467-020-17942-7

Nature Communications (Aug 2020)

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Simona Valletta,
Alexander Thomas,
Yiran Meng,
Xiying Ren,
Roy Drissen,
Hilal Sengül,
Cristina Di Genua,
Claus Nerlov

Affiliations

Simona Valletta: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Alexander Thomas: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Yiran Meng: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Xiying Ren: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Roy Drissen: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Hilal Sengül: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Cristina Di Genua: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
Claus Nerlov: MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford

DOI: https://doi.org/10.1038/s41467-020-17942-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoietic defects, re-balancing haematopoietic stem cell lineage output.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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