Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1

Jianxiu Zhang; Ying-Ying Wang; Zhao-Qian Pan; Yulu Li; Jianhua Sui; Li-Lin Du; Keqiong Ye

doi:10.1038/s41467-022-31439-5

Nature Communications (Jun 2022)

Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1

Jianxiu Zhang,
Ying-Ying Wang,
Zhao-Qian Pan,
Yulu Li,
Jianhua Sui,
Li-Lin Du,
Keqiong Ye

Affiliations

Jianxiu Zhang: Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ying-Ying Wang: College of Life Sciences, Beijing Normal University
Zhao-Qian Pan: National Institute of Biological Sciences
Yulu Li: National Institute of Biological Sciences
Jianhua Sui: National Institute of Biological Sciences
Li-Lin Du: National Institute of Biological Sciences
Keqiong Ye: Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-31439-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Nbr1 recognizes cargos in selective autophagy. Here, authors show filamentous yeast Nbr1 binds Ams1 via an FW domain, and the cryo-EM structure reveals that Nbr1 recognizes the N-terminal di-glycine and tetrameric assembly of Ams1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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