Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8‑Barrel Enzyme of Histidine Biosynthesis HisF

• Enrico Hupfeld,
• Sandra Schlee,
• Jan Philip Wurm,
• Chitra Rajendran,
• Dariia Yehorova,
• Eva Vos,
• Dinesh Ravindra Raju,
• Shina Caroline Lynn Kamerlin,
• Remco Sprangers,
• Reinhard Sterner

Affiliations

Enrico Hupfeld

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany

Sandra Schlee

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany

Jan Philip Wurm

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany

Chitra Rajendran

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany

Dariia Yehorova

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States

Eva Vos

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States

Dinesh Ravindra Raju

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States

Shina Caroline Lynn Kamerlin

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States

Remco Sprangers

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany

Reinhard Sterner

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany