Characteristics of Morbidity of the Tick-Borne Encephalitis in Vaccinated

Abstract

Relevance. Vaccination against the tick-borne encephalitis (TBE), during the mass immunization, by using modern vaccines provides high epidemiological effect (98–99%); however, there are known cases of incidents among vaccinated population. The problem of incidents among vaccinated population is insufficiently studied, likewise a reliability of the diagnostic, vaccination conditions and causes of vaccinated people’s morbidity.Purpose of the article generalization of the information about morbidity among the vaccinated population.Conclusions. The review for the first time provides information about the main issues of this problem: the frequency of illness of vaccinated people in Russia (by federal districts and individual regions), disease development conditions, tied up with vaccination regimens and types of vaccines, clinical features and diagnosis of the disease of vaccinated people. Particular attention is paid to the state of post-vaccination immunity. The significance of two phenomena is being studied: incomplete neutralization of the virus, which leads to the formation of a fraction of a free infectious virus; and the phenomenon of the hyperimmunization with the development of immunological tolerance.

Keywords

• tick-borne encephalitis
• tick-borne encephalitis virus
• vaccine prevention
• patients
• immunity
• hyperimmunization
• neutralization
• incomplete neutralization
• immunological tolerance