Frontiers in Pharmacology (Jul 2021)

CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis

  • Xiang Li,
  • Xiaonan Tang,
  • Yufei Wang,
  • Changwei Chai,
  • Zhehui Zhao,
  • Haijing Zhang,
  • Ying Peng,
  • Lianqiu Wu

DOI
https://doi.org/10.3389/fphar.2021.655101
Journal volume & issue
Vol. 12

Abstract

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Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthritis (CIA). CS-semi5 treatment had obvious effects on weight loss and paw swelling in CIA mice. Post-treatment analysis revealed that CS-semi5 alleviated three main pathologies (i.e., synovial inflammation, cartilage erosion and bone loss) in a dose-dependent manner. Further study showed that CS-semi5 could effectively reduce TNF‐α and IL‐1β production in activated macrophages via the NF‐κB pathway. CS-semi5 also blocked RANKL-trigged osteoclast differentiation from macrophages. Therefore, CS-semi5 may effectively ameliorate synovial inflammation, cartilage erosion and bone loss in RA through NF-κB deactivation.

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