Nature Communications (Mar 2022)
Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors
- Carole Morel,
- Sarah E. Montgomery,
- Long Li,
- Romain Durand-de Cuttoli,
- Emily M. Teichman,
- Barbara Juarez,
- Nikos Tzavaras,
- Stacy M. Ku,
- Meghan E. Flanigan,
- Min Cai,
- Jessica J. Walsh,
- Scott J. Russo,
- Eric J. Nestler,
- Erin S. Calipari,
- Allyson K. Friedman,
- Ming-Hu Han
Affiliations
- Carole Morel
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Sarah E. Montgomery
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Long Li
- Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai
- Romain Durand-de Cuttoli
- Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai
- Emily M. Teichman
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Barbara Juarez
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Nikos Tzavaras
- Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Stacy M. Ku
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Meghan E. Flanigan
- Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai
- Min Cai
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Jessica J. Walsh
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Scott J. Russo
- Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai
- Eric J. Nestler
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Erin S. Calipari
- Friedman Brain Institute, Center for Affective Neuroscience, Icahn School of Medicine at Mount Sinai
- Allyson K. Friedman
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Ming-Hu Han
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-022-29155-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Anxiety and depression are highly comorbid, yet the distinct or shared neurobiological correlates of anxiety remain elusive. Here, Morel et al. define that the midbrain projection to the basolateral amygdala control anxiety but not depression.
