Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

Ryan S. Soderquist; Lorin Crawford; Esther Liu; Min Lu; Anika Agarwal; Grace R. Anderson; Kevin H. Lin; Peter S. Winter; Merve Cakir; Kris C. Wood

doi:10.1038/s41467-018-05815-z

Nature Communications (Aug 2018)

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

Ryan S. Soderquist,
Lorin Crawford,
Esther Liu,
Min Lu,
Anika Agarwal,
Grace R. Anderson,
Kevin H. Lin,
Peter S. Winter,
Merve Cakir,
Kris C. Wood

Affiliations

Ryan S. Soderquist: Department of Pharmacology and Cancer Biology, Duke University
Lorin Crawford: Department of Statistics, Duke University
Esther Liu: Department of Pharmacology and Cancer Biology, Duke University
Min Lu: Department of Pharmacology and Cancer Biology, Duke University
Anika Agarwal: Department of Pharmacology and Cancer Biology, Duke University
Grace R. Anderson: Department of Pharmacology and Cancer Biology, Duke University
Kevin H. Lin: Department of Pharmacology and Cancer Biology, Duke University
Peter S. Winter: Department of Pharmacology and Cancer Biology, Duke University
Merve Cakir: Department of Pharmacology and Cancer Biology, Duke University
Kris C. Wood: Department of Pharmacology and Cancer Biology, Duke University

DOI: https://doi.org/10.1038/s41467-018-05815-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3 mimetics

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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