Stem Cells Therapy for Spinal Cord Injury

Marina Gazdic; Vladislav Volarevic; C. Randall Harrell; Crissy Fellabaum; Nemanja Jovicic; Nebojsa Arsenijevic; Miodrag Stojkovic

doi:10.3390/ijms19041039

International Journal of Molecular Sciences (Mar 2018)

Stem Cells Therapy for Spinal Cord Injury

Marina Gazdic,
Vladislav Volarevic,
C. Randall Harrell,
Crissy Fellabaum,
Nemanja Jovicic,
Nebojsa Arsenijevic,
Miodrag Stojkovic

Affiliations

Marina Gazdic: Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia
Vladislav Volarevic: Faculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, 34000 Kragujevac, Serbia
C. Randall Harrell: Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USA
Crissy Fellabaum: Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USA
Nemanja Jovicic: Faculty of Medical Sciences, Department of Histology and embryology, University of Kragujevac, 34000 Kragujevac, Serbia
Nebojsa Arsenijevic: Faculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, 34000 Kragujevac, Serbia
Miodrag Stojkovic: Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia

DOI: https://doi.org/10.3390/ijms19041039
Journal volume & issue: Vol. 19, no. 4
p. 1039

Abstract

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Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously healthy young adults. Current therapeutic strategies for SCI includes surgical decompression and pharmacotherapy, however, there is still no gold standard for the treatment of this devastating condition. Inefficiency and adverse effects of standard therapy indicate that novel therapeutic strategies are required. Because of their neuroregenerative and neuroprotective properties, stem cells are a promising tool for the treatment of SCI. Herein, we summarize and discuss the promising therapeutic potential of human embryonic stem cells (hESC), induced pluripotent stem cells (iPSC) and ependymal stem/progenitor cells (epSPC) for SCI.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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Abstract

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