Nature Communications (Jun 2019)

SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis

  • Minhoo Kim,
  • Yoonjung Choi,
  • Harim Kim,
  • Daeyoup Lee

DOI
https://doi.org/10.1038/s41467-019-10350-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Stress-inducible transcripts are quickly exported to preserve cell survival when cells are under stress. Here, the authors suggest that Sgf73p of the SAGA deubiquitylating module monitors messenger ribonucleoprotein biogenesis to regulate non-canonical export of stress-inducible transcripts.