THE EFFECT OF AUTOIMMUNE THYROIDITIS ON THE SEVERITY OF ABNORMAL UTERINE BLEEDING

Abstract

The problem of abnormal uterine bleeding does not lose its relevance. Abnormal uterine bleeding occurs at least once in a lifetime in more than 1/2 of women, but only one in four seeks medical attention and is characterized by increased menstrual duration, blood loss, and the number of such episodes. Personal perception of the menstruation norm differs due to socio-cultural and ethnic characteristics. Therefore, patients do not always objectively assess the amount of bleeding and the impact of menstruation on the quality of life, which creates some difficulties in detecting abnormal uterine bleeding. The purpose of the research. To study the levels of hormones of the reproductive system, thyroid gland and anthropometric indicators in women with abnormal uterine bleeding on the pathology of the thyroid gland; establish their interconnections. Material and methods. 55 women aged from 19 to 49 with abnormal uterine bleeding were examined on the background of thyroid diseases, they were included in the main group (group I). The comparison group consisted of patients who had abnormal uterine bleeding without thyroid pathology (group II; n = 30). Research results and discussion. Analysis of proliferative dyshormonal pathology and thyroid function confirmed the dependence of the development of combined proliferative dyshormonal processes of the genitals (hyperplastic syndrome) on hypothyroidism (χ2=101.045, p<0.001) in case of a strong direct correlation between hypothyroidism and hyperplastic syndrome. In the combination of nosological pathologies in women with proliferative dyshormonal diseases of the reproductive organs, uterine leiomyoma was detected in 66.3% of cases, endometrial pathology (hyperplasia, endometrial polyps) was noted in 82.0% of patients, external genital endometriosis was diagnosed in 46.3% of cases, and adenomyosis was detected in 40% of patients. Conclusion. Concomitant extragenital pathology, especially obesity, is common in women with abnormal uterine bleeding and thyroid pathology. Studies of hormones of the reproductive system, thyroid gland and anthropometric parameters in women with abnormal uterine bleeding and thyroid pathology allowed establishing strong correlations among them.

Keywords

• abnormal uterine bleeding
• thyroid pathology
• autoimmune thyroiditis.