Evaluation Gene Expression of Long Non-coding RNA and 5-Hydroxytriptamine 3A Receptor in Bronchial Asthma

Abstract

Background Bronchial asthma is a reversible chronic inflammatory condition of the airways. It is a complex clinical syndrome characterized by airway congestion, inflammation, and hypersensitivity to numerous stim- uli. IncRNAs and the serotonin receptors, named 5-Hydroxytriptamine 3A Receptor (5-HT3A), causes the release of a number of pro-inflammatory cytokines that are crucial in allergic asthma. Aim Present study aimed to evaluate role of gene expression of IncRNA (and 5-HT3A in asthma. Methods In this study, 100 people with bronchial asthma (59 women and 41 men) between the ages of 2 and 61 were compared to 30 healthy people of the same age range (14 women and 16 men). Results current results showed a significant correlation (p<0.05) be- tween 5-HT3A, lncRNA and bronchial asthma when a high gene expres- sion (folding change) of these genes detected in asthmatic patients (2.62 and 2.49 respectively) compared to healthy control (1.00). The increased gene expression of these genes mainly appeared in females (2.05 and 2.03 respectively). Moreover, The highest mean folding of 5-HT3A, lncRNA are looked in patients with familial asthma (2.80 and 2.99) compared to patients without family history (1.11 and 1.01 respectively). Conclusion IncRNA and 5-HT3A play significant role in development of bronchial asthma in present population.

Keywords

• asthma
• 5-ht3a
• lncrna
• gene expression