Human Genome Variation (Feb 2021)
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
- Chakkaphan Runcharoen,
- Koya Fukunaga,
- Insee Sensorn,
- Nareenart Iemwimangsa,
- Sommon Klumsathian,
- Hang Tong,
- Nam Sy Vo,
- Ly Le,
- Tin Maung Hlaing,
- Myo Thant,
- Shamsul Mohd Zain,
- Zahurin Mohamed,
- Yuh-Fen Pung,
- Francis Capule,
- Jose Nevado,
- Catherine Lynn Silao,
- Zeina N. Al-Mahayri,
- Bassam R. Ali,
- Rika Yuliwulandari,
- Kinasih Prayuni,
- Hilyatuz Zahroh,
- Dzul Azri Mohamed Noor,
- Phonepadith Xangsayarath,
- Dalouny Xayavong,
- Sengchanh Kounnavong,
- Somphou Sayasone,
- Zoe Kordou,
- Ioannis Liopetas,
- Athina Tsikrika,
- Evangelia-Eirini Tsermpini,
- Maria Koromina,
- Christina Mitropoulou,
- George P. Patrinos,
- Aumpika Kesornsit,
- Angkana Charoenyingwattana,
- Sukanya Wattanapokayakit,
- Surakameth Mahasirimongkol,
- Taisei Mushiroda,
- Wasun Chantratita
Affiliations
- Chakkaphan Runcharoen
- Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
- Koya Fukunaga
- Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences
- Insee Sensorn
- Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
- Nareenart Iemwimangsa
- Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
- Sommon Klumsathian
- Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
- Hang Tong
- School of Biotechnology, International University, Vietnam National University
- Nam Sy Vo
- Vingroup Big Data Institute
- Ly Le
- School of Biotechnology, International University, Vietnam National University
- Tin Maung Hlaing
- Defence Services Medical Academy
- Myo Thant
- Defence Services Medical Research Centre
- Shamsul Mohd Zain
- Department of Pharmacology, Faculty of Medicine, University of Malaya
- Zahurin Mohamed
- Department of Pharmacology, Faculty of Medicine, University of Malaya
- Yuh-Fen Pung
- Department of Biomedical Sciences, University of Nottingham (Malaysia Campus)
- Francis Capule
- Department of Pharmacy, College of Pharmacy, University of the Philippines Manila
- Jose Nevado
- Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila
- Catherine Lynn Silao
- Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila
- Zeina N. Al-Mahayri
- Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University
- Bassam R. Ali
- Department of Pathology and Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University
- Rika Yuliwulandari
- Department of Pharmacology, Faculty of Medicine, YARSI University
- Kinasih Prayuni
- Genetic Research Center, YARSI Research Institute, YARSI University
- Hilyatuz Zahroh
- Genetic Research Center, YARSI Research Institute, YARSI University
- Dzul Azri Mohamed Noor
- School of Pharmaceutical Sciences, Universiti Sains Malaysia
- Phonepadith Xangsayarath
- National Center for Laboratory and Epidemiology (NCLE)
- Dalouny Xayavong
- National Center for Laboratory and Epidemiology (NCLE)
- Sengchanh Kounnavong
- Lao Tropical and Public Health Institute
- Somphou Sayasone
- Lao Tropical and Public Health Institute
- Zoe Kordou
- University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy
- Ioannis Liopetas
- University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy
- Athina Tsikrika
- University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy
- Evangelia-Eirini Tsermpini
- University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy
- Maria Koromina
- University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy
- Christina Mitropoulou
- The Golden Helix Foundation
- George P. Patrinos
- Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University
- Aumpika Kesornsit
- Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University
- Angkana Charoenyingwattana
- Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
- Sukanya Wattanapokayakit
- Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health
- Surakameth Mahasirimongkol
- Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health
- Taisei Mushiroda
- Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences
- Wasun Chantratita
- Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University
- DOI
- https://doi.org/10.1038/s41439-021-00135-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 6
Abstract
Abstract Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.
