Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Elin S. Blom; Yijing Wang; Lena Skoglund; Anita C. Hansson; Massimo Ubaldi; Anbarasu Lourdusamy; Wolfgang H. Sommer; Matthew Mielke; Bradley T. Hyman; Markus Heilig; Lars Lannfelt; Lars N. G. Nilsson; Martin Ingelsson

doi:10.4061/2011/936580

International Journal of Alzheimer's Disease (Jan 2011)

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Elin S. Blom,
Yijing Wang,
Lena Skoglund,
Anita C. Hansson,
Massimo Ubaldi,
Anbarasu Lourdusamy,
Wolfgang H. Sommer,
Matthew Mielke,
Bradley T. Hyman,
Markus Heilig,
Lars Lannfelt,
Lars N. G. Nilsson,
Martin Ingelsson

Affiliations

Elin S. Blom: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden
Yijing Wang: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden
Lena Skoglund: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden
Anita C. Hansson: Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892-1108, USA
Massimo Ubaldi: Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
Anbarasu Lourdusamy: Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
Wolfgang H. Sommer: Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892-1108, USA
Matthew Mielke: Massachusetts General Hospital, Harvard Medical School, Charlestown, Boston, MA 02119, USA
Bradley T. Hyman: Massachusetts General Hospital, Harvard Medical School, Charlestown, Boston, MA 02119, USA
Markus Heilig: Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892-1108, USA
Lars Lannfelt: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden
Lars N. G. Nilsson: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden
Martin Ingelsson: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden

DOI: https://doi.org/10.4061/2011/936580
Journal volume & issue: Vol. 2011

Abstract

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Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P<.05). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.

Published in International Journal of Alzheimer's Disease

ISSN: 2090-8024 (Print); 2090-0252 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry; Medicine: Internal medicine: Special situations and conditions: Geriatrics
Website: https://onlinelibrary.wiley.com/journal/9730

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