Indian Journal of Pathology and Microbiology (Jan 2018)

Applicability of 2008 World Health Organization classification system of hematolymphoid neoplasms: Learning experiences

  • Sushil Modkharkar,
  • Pooja Navale,
  • Pratibha Kadam Amare,
  • Anuradha Chougule,
  • Nikhil Patkar,
  • Prashant Tembhare,
  • Hari Menon,
  • Manju Sengar,
  • Navin Khattry,
  • Shripad Banavali,
  • Brijesh Arora,
  • Gaurav Narula,
  • Siddhartha Laskar,
  • Nehal Khanna,
  • Mary Ann Muckaden,
  • Venkatesh Rangarajan,
  • Archi Agrawal,
  • Tanuja Shet,
  • Sridhar Epari,
  • P G Subramanian,
  • Sumeet Gujral

DOI
https://doi.org/10.4103/IJPM.IJPM_56_17
Journal volume & issue
Vol. 61, no. 1
pp. 58 – 65

Abstract

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Background: 2008 World Health Organization (WHO) classification of hematolymphoid neoplasms (HLN) has classified them based on morphology, results of various ancillary techniques, and clinical features.[1] There are no studies looking at the applicability of WHO classification. Aims: The aim of the study was to calculate proportions of all HLN subtypes seen during 1-year period based on 2008 WHO classification of HLN and study applicability and also shortcomings of practices in a tertiary care center in India. Materials and Methods: This was a 1-year retrospective study (January 1st, to December 31st, 2010) where cases were identified using hospital/laboratory electronic records. Old follow-up and referral cases were excluded from the study. Only newly diagnosed cases classified into categories laid down by 2008 WHO classification of HLN included. Results: Out of 2118 newly diagnosed classifiable cases, 1602 (75.6%) cases were of lymphoid neoplasms, 489 (23.1%) cases of myeloid neoplasms, 16 (0.8%) cases of histiocytic and dendritic cell neoplasms, and 11 (0.5%) cases of acute leukemias of ambiguous lineage. Overall, most common HLN subtype was diffuse large B-cell lymphoma (n = 361, 17.0%). Precursor B-lymphoblastic leukaemia/lymphoma (n = 177, 48.2%) was the most common subtype within pediatric age group. Conclusions: All major subtypes of HLN were seen at our center and showed trends almost similar to those seen in other Indian studies. Molecular/cytogenetic studies could not be performed on a significant number of cases owing to logistic reasons (unavailability of complete panels and also cost-related issues) and such cases could not be classified as per the WHO classification system.

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