Association of Angiotensinogen Gene M235T and T174M Polymorphisms with Coronary Heart Disease in Rostov Population

Abstract

Objectives: In this study, we examined the relationship between the AGT gene M235T and T174M polymorphisms and CHD risk in Rostov population. Material and Methods: We studied two groups of patients with clinical and coronary angiography evidence of CHD and age- and gender-matched controls, respectively. AGT gene M235T and T174M polymorphisms were analyzed by polymerase chain reaction. Results: The frequency distribution of AGT (M235T) genotypes among patients and controls (M235T: 28.5% and 16.2%; 235T: 22.4% and 7.3%, respectively) was statistically different (P = 0.03 and 0.001, respectively). CHD odds ratio associated with M235T heterozygotes and 235T homozygotes were 2.63 (1.1-6.1) and 4.88 (1.7-13.8), respectively. Conclusion: This study demonstrates the contribution of AGT gene M235T polymorphism, but not the AGT (T174M), to the presence of CHD risk in Rostov population. Genetic association studies involving very large sample size are needed to provide conclusive evidence on the effects of the AGT gene and other genes within the RAS system on risk of CHD.

Keywords

• Coronary heart disease
• Genetic polymorphism
• Angiotensinogen gene
• Risk factor