Nature Communications (May 2022)
The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation
- Binod Kumar,
- Natania S. Field,
- Dale D. Kim,
- Asif A. Dar,
- Yanqun Chen,
- Aishwarya Suresh,
- Christopher F. Pastore,
- Li-Yin Hung,
- Nadia Porter,
- Keisuke Sawada,
- Palak Shah,
- Omar Elbulok,
- Emily K. Moser,
- De’Broski R. Herbert,
- Paula M. Oliver
Affiliations
- Binod Kumar
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Natania S. Field
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Dale D. Kim
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Asif A. Dar
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Yanqun Chen
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Aishwarya Suresh
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Christopher F. Pastore
- Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
- Li-Yin Hung
- Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
- Nadia Porter
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Keisuke Sawada
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Palak Shah
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Omar Elbulok
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- Emily K. Moser
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- De’Broski R. Herbert
- Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
- Paula M. Oliver
- Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia
- DOI
- https://doi.org/10.1038/s41467-022-30437-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Cytokine signaling influences the differentiation of CD4+ T cells into varying functional subsets. Here the authors show that an E3 ubiquitin ligase Cul5 alters TH2 and TH9 development and absence of Cul5 in T cells results in higher levels of allergy-associated IL-4 and IL-9 secreting T cells.
