Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)

Christine C. Waleguele; Brice M. Mba’ning; Angelbert F. Awantu; Jean J. K. Bankeu; Yannick S. F. Fongang; Augustin S. Ngouela; Etienne Tsamo; Norbert Sewald; Bruno N. Lenta; Rui W. M. Krause

doi:10.3390/molecules25122862

Molecules (Jun 2020)

Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)

Christine C. Waleguele,
Brice M. Mba’ning,
Angelbert F. Awantu,
Jean J. K. Bankeu,
Yannick S. F. Fongang,
Augustin S. Ngouela,
Etienne Tsamo,
Norbert Sewald,
Bruno N. Lenta,
Rui W. M. Krause

Affiliations

Christine C. Waleguele: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
Brice M. Mba’ning: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
Angelbert F. Awantu: Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39 Bambili, Cameroon
Jean J. K. Bankeu: Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39 Bambili, Cameroon
Yannick S. F. Fongang: Department of Chemistry, Higher Teacher Training College, The University of Maroua, P.O. Box 55 Maroua, Cameroon
Augustin S. Ngouela: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
Etienne Tsamo: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
Norbert Sewald: Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Bruno N. Lenta: Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon
Rui W. M. Krause: Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa

DOI: https://doi.org/10.3390/molecules25122862
Journal volume & issue: Vol. 25, no. 12
p. 2862

Abstract

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The MeOH/CH2Cl2 (1:1) extracts of the roots and leaves of Beilschmiedia louisii and B. obscura showed potent antitrypanosomal activity during preliminary screening on Trypanosoma brucei brucei. Phytochemical investigation of these extracts led to the isolation of a mixture of two new endiandric acid derivatives beilschmiedol B (1) and beilschmiedol C (2), and one new phenylalkene obscurene A (3) together with twelve known compounds (4–15). In addition, four new derivatives (11a–11d) were synthesized from compound 11. Their structures were elucidated based on their NMR and MS data. Compounds 5, 6, and 7 were isolated for the first time from the Beilschmiedia genus. Additionally, the NMR data of compound 4 are given here for the first time. The isolates were evaluated for their antitrypanosomal and antimalarial activities against Tb brucei and the Plasmodium falciparum chloroquine-resistant strain Pf3D7 in vitro, respectively. From the tested compounds, the mixture of new compounds 1 and 2 exhibited the most potent antitrypanosomal activity in vitro with IC50 value of 4.91 μM.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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