Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Anders P. Mutvei; Michal J. Nagiec; Jens C. Hamann; Sang Gyun Kim; C. Theresa Vincent; John Blenis

doi:10.1038/s41467-020-15156-5

Nature Communications (Mar 2020)

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Anders P. Mutvei,
Michal J. Nagiec,
Jens C. Hamann,
Sang Gyun Kim,
C. Theresa Vincent,
John Blenis

Affiliations

Anders P. Mutvei: Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building
Michal J. Nagiec: Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building
Jens C. Hamann: Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building
Sang Gyun Kim: Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building
C. Theresa Vincent: Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory
John Blenis: Weill Cornell Medicine, Sandra and Edward Meyer Cancer Center, Belfer Research Building

DOI: https://doi.org/10.1038/s41467-020-15156-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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mTORC1 regulates cellular growth from the lysosome, but how changes in the organisation of the lysosomal system affect mTORC1 signalling is poorly understood. Here the authors show that amino acid-dependent Rap1-mediated changes in lysosomal abundance determine overall signalling output of mTORC1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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