PLoS ONE (Jan 2021)

Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices.

  • Haitham Abu Khadija,
  • Gera Gandelman,
  • Omar Ayyad,
  • Mustafa Jaber,
  • Lion Poles,
  • Michael Jonas,
  • Offir Paz,
  • Firas Abu Sbaih,
  • Gal Sella,
  • Sara Shimoni,
  • Jacob George,
  • Alex Blatt

DOI
https://doi.org/10.1371/journal.pone.0258963
Journal volume & issue
Vol. 16, no. 10
p. e0258963

Abstract

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ObjectiveTranscatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes in the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable valves (BEVs) with the consequent inflammatory response remains uncertain.Materials and methodsPatients with severe symptomatic aortic stenosis who underwent transfemoral TAVI: SEVs or BEVs, from January 2010 to December 2019 were enrolled. Whole white blood cells (WBC) and subpopulation dynamics as well the neutrophil to lymphocyte ratio (NLR) were evaluated.ResultsThree-hundred seventy consecutive patients (mean age 81.75 ± 6.8 years, 199 women's) were enrolled. In the entire population, significant kinetic changes in the WBC response (p ConclusionThis is the first description of a differential inflammatory response between the two leading delivery systems. SEV appears to trigger a more robust inflammatory response as compared to BEV. Clinical studies are warranted to assess the long term effect of our findings.