To the issue of differential diagnosis of Hodgkin lymphoma and T-phenotype anaplastic large-cell lymphoma (ALCL)

Abstract

Hodgkin lymphoma differs from anaplastic largecell lymphoma (ALCL) (≪Hodgkin-like≫ variant) by more frequent early stage diseases revealing (46%), mediastinal lymph nodes involvement (69%), softtissue components absence, small number of cases with more than one extranodal organ involvement (15%), ALK-protein absence (100%) and tumor cell B-immunophenotype (PAX 5+). Morphological features: the expressed pironinophilia in tumor cells cytoplasm by Broshe staining in systemic ALCL (T-/0 phenotype), that is rare observed in Hodgkin lymphoma; large tumor cells in systemic ALCL (_-/0 phenotype) have more polymorphic nucleuses with small nucleoluses in comparison with more spherical cells with large nucleoluses in Hodgkin lymphona; intrasinus growth observed almost in a half of cases in systemic ALCL (T-/0 phenotype) does not revealed in Hodgkin lymphoma; tumor tissue fibrosis is a rare observation in systemic ALCL (T-/0 phenotype), while fibrosis and capsule sclerosis are frequent morphological signs in Hodgkin lymphoma.

Keywords

• анапластическая крупноклеточная лимфома
• лимфома ходжкина
• диагностические критерии
• иммунофенотипические особенности
• клиническое течение
• прогностические группы