Nature Communications (Jul 2019)

DNA translocation mechanism of the MCM complex and implications for replication initiation

  • Martin Meagher,
  • Leslie B. Epling,
  • Eric J. Enemark

DOI
https://doi.org/10.1038/s41467-019-11074-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combination of ADP, and ATP-mimic, ADP-BeF3.