Nature Communications (Aug 2019)
Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
- Helen Luck,
- Saad Khan,
- Justin H. Kim,
- Julia K. Copeland,
- Xavier S. Revelo,
- Sue Tsai,
- Mainak Chakraborty,
- Kathleen Cheng,
- Yi Tao Chan,
- Mark K. Nøhr,
- Xavier Clemente-Casares,
- Marie-Christine Perry,
- Magar Ghazarian,
- Helena Lei,
- Yi-Hsuan Lin,
- Bryan Coburn,
- Allan Okrainec,
- Timothy Jackson,
- Susan Poutanen,
- Herbert Gaisano,
- Johane P. Allard,
- David S. Guttman,
- Margaret E. Conner,
- Shawn Winer,
- Daniel A. Winer
Affiliations
- Helen Luck
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Saad Khan
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Justin H. Kim
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Julia K. Copeland
- Centre for the Analysis of Genome Evolution and Function, University of Toronto
- Xavier S. Revelo
- Department of Integrative Biology and Physiology, University of Minnesota
- Sue Tsai
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Mainak Chakraborty
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Kathleen Cheng
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Yi Tao Chan
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Mark K. Nøhr
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Xavier Clemente-Casares
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Marie-Christine Perry
- Department of Immunology, University of Toronto
- Magar Ghazarian
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Helena Lei
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Yi-Hsuan Lin
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- Bryan Coburn
- Department of Immunology, University of Toronto
- Allan Okrainec
- Toronto Western Hospital, University Health Network
- Timothy Jackson
- Toronto Western Hospital, University Health Network
- Susan Poutanen
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Herbert Gaisano
- Department of Medicine, University of Toronto
- Johane P. Allard
- Department of Medicine, University of Toronto
- David S. Guttman
- Centre for the Analysis of Genome Evolution and Function, University of Toronto
- Margaret E. Conner
- Department of Virology and Microbiology, Baylor College of Medicine
- Shawn Winer
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Daniel A. Winer
- Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGRI), University Health Network
- DOI
- https://doi.org/10.1038/s41467-019-11370-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions of IgA in regulating metabolic disease and for intestinal immunity in modulating systemic glucose metabolism.
