S269: MACROPHAGE FUNCTIONAL AND METABOLIC REWIRING THROUGH PPAR/PGC1 MODULATION IMPROVES HEME/IRON-DRIVEN DEFECTIVE EFFEROCYTOSIS AND PROMOTES TISSUE DAMAGE RESOLUTION IN SICKLE CELL DISEASE

• R. Sharma,
• S. Z. Vance,
• A. Antypiuk,
• D. Manwani,
• F. Vinchi

Affiliations

R. Sharma

1 Iron Research Laboratory, New York Blood Center

S. Z. Vance

1 Iron Research Laboratory, New York Blood Center

A. Antypiuk

1 Iron Research Laboratory, New York Blood Center

D. Manwani

2 Pediatric Hematology, The Children’s Hospital at Montefiore, New York, United States of America

F. Vinchi

1 Iron Research Laboratory, New York Blood Center